Trolox inhibits osteoclastogenesis via down‐regulating c‐Fos protein
نویسندگان
چکیده
منابع مشابه
Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling.
Excessive receptor activator of NF-kappaB ligand (RANKL) signaling causes enhanced osteoclast formation and bone resorption. Thus, down-regulation of RANKL expression or its downstream signals may be a therapeutic approach to the treatment of pathological bone loss. In this study, we investigated the effects of Trolox, a water-soluble vitamin E analogue, on osteoclastogenesis and RANKL signalin...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.lb11-a